Data-Driven Spectral Features Of Directional Dbs Electrodes And Ddbs-Ecog Connectivity

Directional DBS electrodes are a novel probe design enabling targeted stimulation of subcortical structures. Here, we leverage methods of broadband time-amplitude correlation and spectral power comparison to demonstrate and characterize the unique directional sensing ability of these novel probes. This work avoids preset frequency banding to highlight the electrode- and anatomy-specific spectral characteristics within each subject's neural recordings. Using precise whole-brain reconstruction, spectral features are associated with specific subcortical structures across six patients implanted for treatment of neurological movement disorders, supporting the utility of directional leads as a tool for biomarker sensing and discovery.