Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on αv Integrins

•Cell-based selections identified inhibitory Abs targeting αv integrins.•Engineered a bispecific Ab targeting two inhibitory epitopes on αv integrins.•The bispecific Ab selectively inhibited integrins αvβ1, αvβ3 and αvβ5.•The bispecific Ab inhibited proliferation and migration of lung cancer cells.•The bispecific Ab is a therapeutic candidate for cancer and fibrosis.