Resting state prefrontal cortex oxygenation in adolescent non-suicidal self-injury – A near-infrared spectroscopy study

•Resting prefrontal cortex (PFC) oxygenation is decreased in adolescents with non-suicidal self-injury (NSSI) compared to healthy controls.•Lower PFC oxygenation (full sample) is associated with greater adverse childhood experiences and less health-related quality of life (HRQoL).•On the group-level, patients show no alterations of resting state functional connectivity within the PFC.•Among other clinical variables, increased PFC connectivity (full sample) is associated with greater borderline personality pathology.