TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy

Daniele Bertoglio,Halima Amhaoul,Joery Goossens,Idrish Ali,Elisabeth Jonckers,Tom Bijnens, Matteo Siano,Leonie wyffels,Jeroen Verhaeghe,Annemie Van der Linden,Steven Staelens,Stefanie Dedeurwaerdere

NeuroImage: Clinical（2021）

引用 11|浏览3

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摘要

•Translocator protein (TSPO) PET imaging identifies different epileptic categories.•TSPO levels at disease onset and chronic disease are unrelated in KASE rats.•TSPO expression changes dynamically during epilepsy.•Histopathology during chronic epilepsy is associated to TSPO levels.•TSPO upregulation during disease progression may be based on two superimposed processes.

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关键词

Translocator protein,Inflammation,PET imaging,Neuroimaging,Kainic acid,KASE

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