Prognostic significance of T cells, PD-L1 immune checkpoint and tumour associated macrophages in clear cell carcinoma of the ovary

Rachel Sue-A-Quan,Palak G Patel,Noor Shakfa, May-Phyo Nyi Nyi,Afrakoma Afriyie-Asante,Eun Young Kang,Martin Köbel,Madhuri Koti

Gynecologic Oncology（2021）

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摘要

•Higher tumour associated macrophage and CD8+ T cell infiltration associates with poor clinical outcomes in patients with CCOC.•Increased PD-L1 and IDO-1 immune checkpoint expression associates with longer survival rates in patients with CCOC.•These novel findings provide the foundation for future developments in immunotherapeutic management of CCOC.

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