A Copper Iodide-Catalyzed Coupling Reaction Of Benzofuran-3(2h)-Ones With Amines: An Approach To Alpha-Ketoamides

A CuI-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines has been well established for the direct synthesis of alpha-ketoamides. This process involves C-O bond cleavage and CvO/C-N bond formation. Mechanism studies indicated that this alpha-ketoamide formation reaction may involve a free radical process.