Native Mass Spectrometry and Gas-Phase Fragmentation Provide Rapid and In-Depth Topological Characterization of a PROTAC Ternary Complex.
Cell chemical biology（2021）
Key words
PROTACs (proteolysis-targeting chimeras),ternary complex,MZ1,native mass spectrometry,ECD (electron capture dissociation),CID (collision-induced dissociation),CIU (collision-induced unfolding),IMS (ion mobility spectrometry),charge-reducing agent,E3 ligase
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