Validation of using cardioplegic solutions for preserving cardiac function in isolated rabbit heart assays

Ziva Arimura,BaoXi Gao,Mei Fang,Hugo M Vargas,Yusheng Qu

Journal of Pharmacological and Toxicological Methods（2021）

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摘要

Cardiac function was preserved after cardioplegic treatment, however, coronary flow rates were decreased (-19.3%) in C-IRH hearts which indicated an altered coronary vascular tone. In conclusion, storage in cardioplegic solution preserves rabbit cardiac function, a practice that enables heart tissues to be collected at one site (e.g., vivarium) and transported to a laboratory in a separate location.

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关键词

Cardiac function,Cardioplegia,Cardioplegic solution,Contractility,Coronary flow,Electrocardiography,Isolated rabbit heart,Langendorff,Methods,Rabbit

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