Solid-Phase Synthesis Of Gly-Psi[Ch(Cf3)Nh]-Peptides

The solid-phase synthesis of Gly-Psi[CH(CF3)NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Psi[CH(CF3)NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogues of biological relevant peptides, have been obtained in high purity.