Imaging The Effect Of Ketamine On Synaptic (Sv2a) Density

Sophie Holmes,Sjoerd Finnema,Mika Naganawa,Nicole DellaGioia,Daniel Holden,Krista Fowles,Jim Ropchan,Paul Emory,Yunpeng Ye,Nabeel Nabulsi,David Matuskey,Gustavo Angarita,Ronald Duman,Gerard Sanacora,John Krystal,Richard Carson,Irina Esterlis

BIOLOGICAL PSYCHIATRY（2021）

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摘要

Ketamine is thought to exert its rapid antidepressant effects through restoration of lost synaptic connections. Using PET and [11C]UCB-J, a radioligand that binds to the synaptic vesicle protein 2A (SV2A), we previously showed that lower synaptic density is associated with depression severity. Here, we determined whether ketamine results in an increase in SV2A density.

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关键词

Ketamine, Depression, Synapse, PET

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