η 6 ‐arene CH‐O Interaction Directed Dynamic Kinetic Resolution – Asymmetric Transfer Hydrogenation (DKR‐ATH) of α‐keto/enol‐lactams

Zhonghua Luo,Guodong Sun,Shuming Wu,Yong Chen,Yicao Lin,Lei Zhang,Zhongqing Wang

Advanced Synthesis & Catalysis（2021）

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摘要

A dynamic kinetic resolution – asymmetric transfer hydrogenation (DKR‐ATH) methodology of α‐keto/enol‐lactams was developed. We also propose a possible catalytic mechanism evolving a transition state stabilized by η6‐arene CH−O interaction. The efficient approach can be applied to a wide range of substrates including non‐aryl ones which would be difficult to prepare by other asymmetric reduction methods.

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关键词

Dynamic kinetic resolution-asymmetric transfer hydrogenation,enatioselectivity,lactams,CH−O interaction,mechanism

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