Chemical Constituents From Laggera Pterodonta And Their Anti-Inflammatory Activities In Vitro

A phytochemical investigation on the aerial parts of Laggera pterodonta resulted in the isolation and identification of 23 compounds, including twelve sesquiterpenoids (1-12), two norisoprenoids (13, 14), three alkaloids (1517), one lignan (18), and five flavonoids (19-23). Among them, norpterodonols A (1) and B (2) are two undescribed norsesquiterpenoid derivatives. Their structures were established on the basis of NMR and HR-ESI-MS spectroscopic analysis. All isolates were evaluated for their inhibitory effects on the NO production in LPSinduced RAW 264.7 macrophages, and compounds 8, 10, 16, 18, 20, 21, and 23 were shown to have obvious anti-inflammatory effects.