Microscopic Colitis and Risk of Colon Adenomas: A Multicenter Retrospective Cohort Study

Microscopic colitis (MC) is a common cause of chronic watery diarrhea, with the highest incidence in women over age 50. Cross-sectional studies have suggested that patients with MC have a lower incidence of adenomatous colon polyps compared with those without MC. The existing literature is limited by cross-sectional design, small sample sizes, lack of longitudinal follow-up, and the use of average-risk patients, rather than those with chronic diarrhea, as controls. We aimed to explore the association between MC and colon adenomas.