PCSK9 and cancer: Rethinking the link

Khadijeh Mahboobnia,Matteo Pirro,Ettore Marini,Francesco Grignani,Evgeny E. Bezsonov,Tannaz Jamialahmadi,Amirhossein Sahebkar

Biomedicine & Pharmacotherapy（2021）

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摘要

•PCSK9 is a serine protease modulating cholesterol metabolism by attachment to the LDL receptor.•Recent literature suggests that PCSK9 is associated with incidence and progression of several cancers.•Herein, we reviewed how PCSK9 acts in cancer pathophysiology.•We also explored potential risks or benefits associated to PCSK9 inhibition in cancer.

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关键词

PCSK9,Cancer,LDL cholesterol,LDL receptor,Monoclonal antibodies,Vaccine,Safety

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