Clinical Outcomes of Daptomycin Versus Anti-Staphylococcal Beta-Lactams in Definitive Treatment of Methicillin-susceptible Staphylococcus aureus Bloodstream Infections

•Staphylococcus aureus is a leading cause of bacteraemia and endocarditis worldwide•The preferred therapy for Staphylococcus aureus bacteraemia is an anti-staphylococcal beta-lactam•Comparable clinical outcomes were demonstrated with daptomycin therapy•Increased daptomycin length of stay may reflect complications from prior therapy•Daptomycin may be an option when anti-staphylococcal beta-lactams cannot be used