Regulation Of Autophagy By Vps34 Branched Ubiquitination Controls Proteostasis And Liver Metabolism
MOLECULAR & CELLULAR ONCOLOGY(2021)
摘要
Ubiquitin-proteasome system and autophagy are the two major recycling processes. Our recent work uncovers a K29/K48 branched ubiquitination on the phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3, best known as VPS34). This ubiquitination is positively or negatively regulated under pathophysiological conditions to influence on autophagy, proteostasis and lipid homeostasis.
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关键词
Autophagy, branched ubiquitination, vps34, liver steatosis, protein quality control
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