Aortic Dimensions, Biophysical Properties, and Plasma Biomarkers in Children and Adults with Marfan or Loeys-Dietz Syndrome.

Jason Z Cui,Kevin C Harris,Koen Raedschelders,Zsuzsanna Hollander,James E Potts,Astrid De Souza,Marla Kiess,Bruce M McManus,Pascal Bernatchez,Leslie A Raffin,Heidi Paine,Cornelis van Breemen,George G S Sandor,Mitra Esfandiarei

CJC open（2021）

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摘要

Despite the increased PWV, monitoring aortic stiffness or TGF-β levels would not be helpful in patients with MFS. TGF-β levels were not increased and the increased MMP-2 levels suggest consideration of a different therapeutic target.

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