Determination of misoprostol acid in plasma samples by UPLC–MS/MS with application in a maternal-fetal pharmacokinetic study following a low misoprostol dose vaginally to induce labor

Gabriela Campos de Oliveira Filgueira,Grazielle de Fátima Pinto Rodrigues,Jhohann Richard de Lima Benzi,Glauco Henrique Balthazar Nardotto,Maria Paula Marques,Vera Lucia Lanchote,Ricardo Carvalho Cavalli

Journal of Pharmaceutical and Biomedical Analysis（2021）

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摘要

•A validated method for MA analysis in plasma with the lowest LLOQ.•Application in a maternal-fetal pharmacokinetic study.•Method applied in a study of low misoprostol dose of 25 μg administered vaginally.•First report of MA PK following misoprostol 25 μg administered vaginally.•MA showed high placental transfer with accumulation in the fetal compartment.

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关键词

Misoprostol,Misoprostol acid,Pregnancy,Placental transfer,Pharmacokinetics,UPLC–MS/MS

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