Phosphorylated α-synuclein and phosphorylated tau-protein in sural nerves may contribute to differentiate Parkinson’s disease from multiple system atrophy and progressive supranuclear paralysis

Zhe Rong,Feifei Shen, Ye Wang,Li Sun,Jing Wu,Hui Zhang,Yongsheng Yuan,Wenwen Jiang,Xiao Li,Pan Ji,Kezhong Zhang

Neuroscience Letters（2021）

引用 8|浏览7

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摘要

•Peripheral sensory nerve was impaired in PD, MSA and PSP.•p-α-syn and p-tau in sural nerve may serve as novel biomarkers for differential diagnosis of PD, MSA and PSP.•Schwann cells might perform an important role in peripheral pathophysiological processes of PD, MSA and PSP.

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关键词

CNS,CTRs,GCIs,HC,H–Y staging,LEDD,MMSE,MRI,MSA,NA,NF,NMSS,PD,PNS,p-α-syn,PSP,p-tau,SCs,SD,t-α-syn,UMSARS,UPDRS,UPSPRS

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