Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors

Vinciane Saint-Criq,Yiting Wang,Livia Delpiano,JinHeng Lin,David N Sheppard,Michael A Gray

Journal of Cystic Fibrosis（2021）

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摘要

•CFTR correctors rescue the plasma membrane expression of F508del-CFTR.•Extracellular phosphate enhances F508del-CFTR function rescued by CFTR correctors.•Cystic fibrosis airway epithelia express the phosphate transporter SLC34A2.•Extracellular phosphate levels might contribute to variable drug responses.

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关键词

F508del-CFTR,CFTR correctors,Elexacaftor-tezacaftor-ivacaftor (Trikafta),Airway epithelia,Phosphate,SLC34A2

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