Peripheral blood B cell subset ratios and expression levels of B cell-associated genes are altered in benign multiple sclerosis

Recai Turkoglu,Vuslat Yilmaz,Ozkan Ozdemir,Ece Akbayir,Gulcin Benbir,Erdil Arsoy,Melis Sen,Canan Ulusoy,Selen Ozyurt,Nesrin Balic,Elif Sanli,Cem Ismail Kucukali,Derya Karadeniz,Erdem Tuzun

Multiple Sclerosis and Related Disorders（2021）

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摘要

•Sleep and cognitive functions are equally impaired in benign (BMS) and non-benign MS (NBMS).•Memory B cells are reduced and regulatory B cells are increased in BMS.•NBMS patients showed reduced expression levels of B-cell related genes BLK and FCRL2.•B-cell related genes FCRL2, BLNK, BLK and BANK1 correlated with measures of disability.

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关键词

Multiple sclerosis,Benign,B cell,Sleep,Cognition,Autoimmunity

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