Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development

Vishnu V Krishnamurthy,Hyojeong Hwang,Jia Fu,Jing Yang,Kai Zhang

Journal of Molecular Biology（2021）

引用 9|浏览5

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摘要

•Light-dependent cytoplasm-to-membrane translocation of LRP6 activates canonical Wnt signaling.•Optogenetic activation of OptoLRP6opt results in axis duplication in Xenopus laevis.•Axis duplication results from the formation of ectopic Spemann Organizer.

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关键词

optogenetics,Wnt signaling,axis duplication,Xenopus laevis

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