Case Report: Convalescent Plasma Achieves Sars-Cov-2 Viral Clearance In A Patient With Persistently High Viral Replication Over 8 Weeks Due To Severe Combined Immunodeficiency (Scid) And Graft Failure

Verena Keitel,Johannes Georg Bode,Torsten Feldt,Andreas Walker,Lisa Müller, Anselm Kunstein, Caroline Klindt, Alexander Killer,Tina Senff,Jörg Timm, Philipp Ostermann, Maximilian Damagnez,Nadine Lübke,Ortwin Adams,Heiner Schaal,Gerald Antoch,Jennifer Neubert,Philipp Albrecht, Sven Meuth, Saskia Elben, Annemarie Mohring,Johannes C. Fischer,Edwin Bölke,Manfred Hoenig,Ansgar S. Schulz,Tom Luedde,Björn Jensen

FRONTIERS IN IMMUNOLOGY（2021）

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摘要

We describe the unique disease course and cure of SARS-CoV-2 infection in a patient with SCID and graft failure. In absence of a humoral immune response, viral clearance was only achieved after transfusion of convalescent plasma. This observation underscores the necessity of the humoral immune response for SARS-CoV-2 clearance.

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SARS-CoV-2, severe combined immunodeficiency, humoral immune response, convalescent plasma, remdesivir

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