Effects of a Multimerized Recombinant Autoantibody Against Amyloid-β

Alexandra Albus,Yannick Kronimus,Sascha Neumann,Natascha Vidovic, André Frenzel, Philipp Kuhn,Marc Seifert,Tamar Ziehm,Hendrik van der Wurp,Richard Dodel

Neuroscience（2021）

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摘要

•Production of recombinant antibodies on the basis of naturally occurring autoantibodies.•Altered scFv-Fc construct showed multimerisation of antibody.•Multimeric scFv-Fc antibody improved binding and functionality to amyloid-β.•scFv-Fc antibody displayed reactivity to monomeric and oligomeric amyloid-β.•Glycosylation pattern of recombinant antibodies reveal possible issues of therapeutic antibodies.

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关键词

Aβ,AD,ADCC,ADCP,δ,Fc,Fcγ,Fv,IL,IVIg,Ka,KD,Kd,MAHA,Mrd,nAbs,OHSC,Po,RU,scFv-Fc,TNF-α

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