BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity

Benoit Bailly,Luc Guilpain,Kevin Bouiller,Catherine Chirouze, Melissa N'Debi,Alexandre Soulier,Vanessa Demontant,Jean-Michel Pawlotsky,Christophe Rodriguez,Slim Fourati

CLINICAL INFECTIOUS DISEASES（2022）

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摘要

We report an outbreak of severe acute respiratory syndrome coronavirus 2 501Y.V2 in a nursing home. All nonvaccinated residents (5/5) versus half of those vaccinated with BNT162b2 (13/26) were infected. Two of 13 vaccinated versus 4 of 5 nonvaccinated residents presented severe disease. BNT162b2 did not prevent the outbreak, but reduced transmission and disease severity.

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SARS CoV-2, outbreak, variant, BNT162b2 vaccine, nursing home

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