Radiomic features of plaques derived from coronary CT angiography to identify hemodynamically significant coronary stenosis, using invasive FFR as the reference standard

•Over 1000 radiomic features of coronary plaques provided more quantitative information than that provided by conventional analysis.•The radiomics model outperformed the conventional method assessment in the prediction of hemodynamically significant stenosis.•Radiomic feature analysis of coronary plaques provides a noninvasive approach to identify the ischemic coronary stenosis.