Polymorphisms In Glia Maturation Factor 13 Gene Are Markers Of Cellulose Ether Effectiveness In Prion-Infected Mice

Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the two mouse lines showing a dramatic difference in CE effec-tiveness revealed a distinct polymorphism in the glia maturation factor 13 gene. This polymorphism was significantly associated with the CE effectiveness in various prion-infected mouse lines. Sequencing of this gene and its vicinity genes also revealed several other polymorphisms that were significantly related to the CE effectiveness. These polymorphisms are useful as genetic markers for finding more suitable mouse lines and exploring the genetic factors of CE effectiveness. (c) 2021 Elsevier Inc. All rights reserved.