Multigene Panel Testing for Hereditary Cancer and Genetic Counseling

TRANSLATIONAL RESEARCH IN BREAST CANCER(2021)

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摘要
As sequencing technology and information of the genomic causes for cancer development expand, multi-gene panel testing for hereditary cancer is increasing in clinical practice. In this chapter, we reviewed the application of multi-gene panel with pre-/post- testing considerations and summarized genetic counseling based on panel testing results in clinical field. In addition, we introduce multi-gene panel for hereditary cancer developed in Seoul National University Hospital.
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关键词
Hereditary/familial breast cancer, Breast cancer susceptibility, Multigene panel testing, Next-generation sequencing, High penetrance gene, Genetic counseling, BRCA1/2 gene mutation
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