Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma
JOURNAL OF ANTIBIOTICS(2021)
摘要
Antitubercular lanostane triterpenoids isolated from mycelial cultures of the basidiomycete Ganoderma australe were structurally modified by semisynthesis. One of the synthetic compounds, named GA003 ( 9 ), showed more potent activity against Mycobacterium tuberculosis H37Ra than the lead natural lanostane ( 1 ). GA003 was also significantly active against the virulent strain (H37Rv) as well as extensively drug-resistant tuberculosis strains.
更多查看译文
关键词
Drug discovery and development,Lead optimization,Life Sciences,general,Microbiology,Medicinal Chemistry,Organic Chemistry,Bacteriology,Bioorganic Chemistry
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要