Comparison Of Mechanisms Of Kinetochore Capture With Varying Number Of Spindle Microtubules
PHYSICAL REVIEW RESEARCH(2020)
摘要
The biophysical mechanisms of kinetochore capture by spindle microtubules within cells are stochastic processes with a moving target searched by multiple walkers inside a confined volume. We study and compare two such mechanisms: dynamic instability-driven search and capture, common in many eukaryotes, and angular diffusion of pivoted microtubules reported in fission yeast. Characteristic times associated with the rare events of capture scale as a power law with the microtubule number, and their comparison provides a physical basis for the selection of one mechanism over another.
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