Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2

Jinxin Che,Zhilong Wang,Zheyuan Shen,Weihao Zhuang,Huazhou Ying,Yongzhou Hu,Youhong Hu,Xin Xie,Xiaowu Dong

ACS Medicinal Chemistry Letters（2021）

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摘要

CXC chemokine receptors 1 (CXCR1) and 2 (CXCR2) have been demonstrated to have critical roles in cancer metastasis. Because they share high homology sequences, it is still unclear how to design sel...

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关键词

cancer metastasis, CXCR1, CXCR2, selectivity, antagonist, 1,5-dihydro-4H-imidazol-4-one

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