Berberine induces apoptosis and arrests the cell cycle in multiple cancer cell lines.
Archives of Medical Science(2023)
摘要
Berberine exhibited cytotoxic effects on multiple cancer cell lines by inducing apoptosis and cell cycle arrest. The BCL-2/BAX signaling pathway may be the common pathway underlying the anti-tumor effect of berberine. The findings support the notion that berberine is a dietary compound that can be further developed into a drug candidate for cancer treatment.
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关键词
berberine, human epithelial cancer cells, MTT assay, apoptosis, BCL-2, BAX
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