Solubility Measurement Of Crystal Form Ii And Form V Ticagrelor In Several Pure Organic Solvents

Ticagrelor (TCG) is a P2Y(12) platelet inhibitor and has several crystal forms including Form II and Form V. In this work, it has been confirmed that Form II TCG would gradually transform to Form V in selected solvents. According to the crystal form stability, a dynamic method was adopted to measure the solubility of Form II TCG in six pure solvents (n-propanol, isopropanol, n-butanol, 2-butanol, ethyl acetate, and isopropyl acetate). The solubility of Form V TCG in 12 pure solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, 2-butanol, methyl acetate, ethyl acetate, isopropyl acetate, acetone, 2-butanone, and cyclohexanone) was measured by a static method. The solubility measurement temperature range was from 273.15 to 313.15 K. The experimental solubility data were correlated by the modified Apelblat model and the lambda h model. It was shown that the calculated solubility was consistent with the experimental data.