A Case of Small Cell Lung Carcinoma Harboring an EML4–ALK Fusion with Partial Response to Crizotinib

Qian Shen,Farhin Shaheed Kalyani,Jingjing Qu,Zhen Chen,Jing Zhang,Jianying Zhou

Clinical Lung Cancer（2021）

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摘要

•A patient with metastatic small cell lung cancer (SCLC) had an echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) fusion.•He had a partial response to crizotinib in the primary lesions.•ALK tyrosine kinase inhibitors should be considered in SCLC patients with EML4–ALK fusions.•Gene testing should be performed in young SCLC patients with a limited smoking history.

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关键词

SCLC,EML4-ALK,Crizotinib,Partial response,Gene testing

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