In silico studies of semi-synthetic benzo[a]phenazines as inhibitors of dihydrofolate reductase from Plasmodium falciparum

•Phenazines can bind to P. falciparum dihydrofolate reductase (PfDHFR).•In silico comparisons between phenazines and a PfDHFR inhibitor were performed.•3-sulphonyl-lapazine is promising as lead compound for new PfDHFR inhibitors.