Microwave-Assisted Reactions: Efficient And Versatile One-Step Synthesis Of 8-Substituted Xanthines And Substituted Pyrimidopteridine-2,4,6,8-Tetraones Under Controlled Microwave Heating

Ramadan Ahmed Mekheimer,Alaa M. Hayallah,Moustafa Sherief Moustafa,Saleh Mohammed Al-Mousawi,Mohamed Abd-Elmonem,Sara M. Mostafa,Fatma A. Abo Elsoud,Kamal Usef Sadek

GREEN PROCESSING AND SYNTHESIS（2021）

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摘要

We report herein a simple and efficient one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4, 6, 8-tetraones via reaction of 1,3 -dimethyl-5, 6-diaminouracil 1 with activated double bond systems 2 assisted by controlled microwave irradiation. The obtained heterocycles are privileged biologically relevant scaffolds.

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关键词

8-substituted xanthines, pyrimidopetridines, 5,6-diaminouracil, green synthesis

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