Early protein C activation is reflective of burn injury severity and plays a critical role in inflammatory burden and patient outcomes

Ruilong Zhao, Thomas Charles Lang,Albert Kim,Aruna Wijewardena,John Vandervord,Rachel McGrath,Gregory Fulcher,Meilang Xue,Christopher Jackson

Burns（2022）

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摘要

•Activated protein C increases from a nadir on Day 3 following a severe burn injury.•More severe burns trigger greater protein C activation and a functional depletion.•Loss of this cytoprotective agent leads to elevated inflammation and worse outcomes.•The protein C system provides ideal burns biomarkers with therapeutic potential.

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关键词

Activated protein C,Severe burns,Inflammatory cytokine,Biomarker,Clinical outcome

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