Current Approaches to Management of High‐Risk Multiple Myeloma

The median overall survival in multiple myeloma is rapidly approaching 10 years; however, in nearly a fifth of patients the prognosis remains poor. Therefore, the modern-day management of myeloma patients should be individualized, with more intense and continuous approach in these high-risk patients. This includes first-line treatment based on multi-drug combinations employing the most effective drugs combinations, upfront autologous stem cell transplantation (in eligible patients with tandem transplantation being a consideration), and maintenance based on proteasome inhibitor-based combinations. This paper reviews the results of recent retrospective analyses and clinical trials, but also gives a glance into future by presenting the ongoing trials. This article is protected by copyright. All rights reserved.