Cell Free Dna Levels In Patients With Acute Rejection After Lung Transplantation
JOURNAL OF HEART AND LUNG TRANSPLANTATION(2021)
摘要
Purpose The incidence of acute cellular rejection (ACR) in lung transplant recipients (LTRs) remains about 33% in the first-year post-transplant, the highest for any organ transplant. Although acute rejection frequently responds to treatment, at the present time there is no reliable biomarker to non-invasively monitor response to therapy after ACR treatment . We hypothesized %ddcfDNA levels following acute rejection treatment can predict response to therapy. Methods We retrospectively collected clinical and histopathology data on lung transplant recipients treated for ACR who underwent %ddcfDNA testing as part of clinical care between March 2020 and August 2020. Results We identified a total of 14 LTRs that were treated for ACR and had a %ddcfDNA value available. One patient had only one %ddcfDNA and was excluded from the analysis. 11/13 patients also had available %ddcfDNA values after treatment. 10/11 of these patients demonstrated a decline in %ddcfDNA level following treatment of rejection(figure 1) The mean reduction in %ddcfDNA after treatment was 55% (Log10 Ratio -0.35; 95% CI, 9% to 78%; p = 0.03). One patient had a significant increase in follow up %ddcfDNA level attributed to persistent ACR and antibody mediated rejection(AMR) requiring Anti-Thymocyte Globuline(ATG) treatment. Subsequent values for this patient also demonstrate that %ddcfDNA levels decrease following aggressive treatment of rejection. One patient(patient 6) had concurrent infection and rejection. Conclusion %ddcfDNA may to be a useful biomarker in evaluating allograft post rejection treatment. Persistent high levels are suggestive of ongoing ACR or AMR
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