SERS-Based Ultrasensitive Lateral Flow Assay for Quantitative Sensing of Protein Biomarkers
IEEE Journal of Selected Topics in Quantum Electronics(2021)
摘要
The remarkable optical properties of surface-enhanced Raman scattering (SERS) has prompted the design and fabrication of SERS nanoparticles as biosensing and imaging labels. Among a variety of biosensing assay platforms within the growing point of care technology (POCT) field, lateral flow assay (LFA) has gained significant attention because of their simplicity, low cost, and user-friendly assay protocols. Herein, we show the development and performance benchmarking of SERS-based LFA for rapid and quantitative sensing of two important biomarkers: hCG and cTnT. The results suggest the feasibility of this platform for POCT applications.
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关键词
Laser biomedical applications,lateral flow assay (LFA),nanotechnology,plasmons,surface enhanced raman scattering (SERS)
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