Factors affecting platelet yield in single donor plateletpheresis: A single institution experience

Transfusion of single donor platelets (SDP) is emerging as effective therapy in patients with platelet(PLT) insufficiencies with the advantage of preventing alloimmunisation and transfusion related infections by limiting recipient’s exposure to platelets from multiple donors.\nThe aim of the present study is to analyze the effect of various donor and procedure related parameters on the yield of single donor platelets facilitating effective screening of blood donors in less time.\nMaterials and Methods: It is a reterospective study of one hundred and nine plateletpheresis procedures performed at our (tertiary-care) hospital over a period of 16 months.The procedure was carried on Fresinius. Kabi COM.TEC apheresis machine (contious flow cell seperator) using closed system kits, single needle procedure with program selected 5d-SN. Statistical analysis was done with SPSS software to find the extent of relationship between different variables using “r” value and “p” value.\nResults: Age, weight, plateletcount,haemoglobin(Hb), total leucocyte count(TLC) and blood volume processed of donors, processing time of machine had significant positive correlation with platelet yield. ABO group did not show any correlation with platelet yield.Rh negative donors had longer processing time than Rh positive donors.\nConclusion: Platelet yield correlated positively with pre-donation platelet count, weight, haemoglobin, processing time and blood volume processed. Optimization of platelet yield by identifying donor factors may help in selecting donors to obtain higher platelet yields in shorter time and consequently better clinical outcome.\n\nKeywords: Plateletpheresis; Haemoglobin; Total leucocyte count; Weight; Platelet Count; Platelet yield