The matricellular receptor LRP-1 acts as a pro-tumorigenic receptor by supporting tumor angiogenesis in a triple negative breast cancer model

LRP-1 (low-density lipoprotein receptor-related protein-1) receptor is a multifunctional endocytosis receptor that is part of the LDL receptor family. Due to its capacity to control the pericellular level of various growth factors and proteases, LRP-1 plays a crucial role in controlling the dynamics of the membrane proteome. [1] LRP-1 overexpression in breast cancer and in particular in triple negative breast cancer (TNBC), prompted us to take an interest in its involvement in tumor progression and more specifically to the role it could play in controlling angiogenesis. For that purpose, an RNA interference strategy in a TNBC model (MDA-MB-231 line) in vivo was used, based on shRNA stable expression. 42 days following an orthotopic injection of shLRP-1 MDA-MB-231 cells (in which LRP-1 expression is repressed by 70%) and shCtrl MDA-MB-231 cells (comparable to wild type MDA-MB-231 cells) in BALB/c nude mice, a delay of 40% in tumor growth was observed (257 mm3 vs 432 mm3, p Citation Format: Oceane Campion, Jessica Thevenard-Devy, Nicolas Etique, Anne-Aurelie Raymond, Jean-William Dupuy, Stephane Dedieu, Jerome Devy. The matricellular receptor LRP-1 acts as a pro-tumorigenic receptor by supporting tumor angiogenesis in a triple negative breast cancer model [abstract]. In: Proceedings of the AACR Virtual Special Conference on the Evolving Tumor Microenvironment in Cancer Progression: Mechanisms and Emerging Therapeutic Opportunities; in association with the Tumor Microenvironment (TME) Working Group; 2021 Jan 11-12. Philadelphia (PA): AACR; Cancer Res 2021;81(5 Suppl):Abstract nr PO020.