Dna Methyltransferase Inhibitor Guadecitabine Combined With Cisplatin And Gemcitabine Chemotherapy (Spire): Randomized Expansion Phase As Neoadjuvant Therapy For Bladder Urothelial Carcinoma.

Simon J. Crabb,Sarah Danson,James Wf Catto,Syed A. Hussain,Denise Dunkley,Nichola Downs,Geoff Saunders,Michelle Light,Naveed Sarwar,Deborah Enting,Alison Jane Birtle,Amir El Ghzal,Bernadette Johnson,Robert A Huddart,Gareth Owen Griffiths

JOURNAL OF CLINICAL ONCOLOGY（2021）

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447Background: Pre-clinical data support a hypothesis that DNA methyltransferase inhibition will circumvent cisplatin resistance in various cancers including urothelial carcinoma (UC). SPIRE compri...

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