A case of coagulation factor XIII deficiency which was diagnosed by examinations immediately before tooth extraction

Coagulation factor XIII (F-XIII) deficiency is a rare disorder characterized by hemorrhagic diathesis, leading to defective wound healing and prolonged bleeding after trauma. This report describes tooth extraction in a 29-year-old man with F-XIII deficiency. A year earlier, he had experienced odontorrhagia and had been transported to hospital after extraction of the left mandibular third molar. Extensive blood examination was therefore performed this time, revealing F-XIII deficiency (activity level, 25%). Therefore, concentrated F-XIII was administered to increase F-XIII activity before extraction, increasing the F-XIII activity level to 61%. Teeth were then extracted under local anesthesia. Subsequent wound healing was favorable without odontorrhagia. In this time, we described the extremely rare report of F-XIII deficiency diagnosed by examinations immediately before dental treatments that included tooth extraction.