Survival Outcome After Interval Cytoreductive Surgery in Advanced-Stage Epithelial Ovarian Carcinoma: A Tertiary Care Centre Experience

Objective To assess the survival outcome and morbidity pattern after interval cytoreduction surgery done for FIGO stage III and IV epithelial ovarian cancer, not amenable to primary cytoreduction. Methods This is a retrospective study of patients diagnosed with advanced-stage epithelial ovarian cancer who underwent interval cytoreduction from January 2014 to December 2016. Morbidity profile was assessed using descriptive statistics and Chi-square test for statistical significance. Overall and disease-free survival was calculated using Kaplan–Meier method and log-rank test for statistical significance. Postoperative complications were graded according to Clavien–Dindo grading system. Results Patients who attained OCR during ICR had better progression-free survival (PFS) at the end of 3 years compared to patients who could not achieve OCR during ICR ( p = 0.014). There was no significant difference in OS between stages III and IV but stage III patients had better PFS comparing to stage IV patients (but p value was not significant). There was no significant postoperative morbidity after ICR. Conclusion After neoadjuvant chemotherapy, OCR could be achieved in around 80% of advanced-stage epithelial ovarian cancer. At age less than 70 years, attainment of optimal cytoreduction during interval cytoreduction was associated with significant PFS at the end of 3 years.