Decidualization modulates the mesenchymal stromal/stem cell and pericyte characteristics of human decidual stromal cells. Effects on antigen expression, chemotactic activity on monocytes and antitumoral activity
Journal of Reproductive Immunology(2021)
摘要
•During decidualization, the endometrial mesenchymal stem cells markers CD140b, CD146, SUSD2 and α-SM actin are downmodulated by DSCs.•DSCs secrete chemotactic factors for monocytes and this activity increases in decidualization.•Decidualized DSCs, but not undifferentiated DSCs, secrete antitumoral factors.
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关键词
α-SM actin,ANGPT1,APC,CD,CM,CXCL12,dDSC,DSC,eMSC,FGF2,HGF,MSC,NFC,P4,PFA,PGF,PreDSC,PRL,SUSD2,VEGF,WJ-MSC
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