Region-specific Effects of Early-life Status Epilepticus on the Adult Hippocampal CA3 – Medial Entorhinal Cortex Circuitry In vitro: Focus on Interictal Spikes and Concurrent High-frequency Oscillations

•Early-life Status Epilepticus (SE) impacts on the adult hippocampal – entorhinal communication in the in vitro 4-AP model.•Post-SE CA3 output decreases in HFO power with no change in interictal discharge frequency.•Post-SE mEC output increases both in HFO power and interictal discharge frequency.•Interictal HFO dynamics in CA3-mEC change upon the connectivity state of the two areas and prior history of early-life SE.