Vitamin B12 Induces Hepatic Fatty Infiltration through Altered Fatty Acid Metabolism.

Joseph Boachie,Antonysunil Adaikalakoteswari,Antonio Gázquez,Victor Zammit,Elvira Larqué,Ponnusamy Saravanan

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2021）

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摘要

Our data provide novel evidence that low B12 increases fatty acid synthesis and levels of individual fatty acids, and decreases fatty acid oxidation and mitochondrial respiration, thus resulting in dysregulation of lipid metabolism in HepG2. This highlights the potential significance of de novo lipogenesis and warrants possible epigenetic mechanisms of low B12.

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关键词

Vitamin B12, Lipogenesis, Fatty acid oxidation, Dyslipidaemia, Hepatocyte, Triglyceride

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