Estimands-What They Are And Why They Are Important For Pharmacometricians

We provide a brief introduction to estimands and share our perspective on why we think estimands are helpful for the practicing pharmacometrician. The discussion is motivated by the recent release of the International Council for Harmonisation (ICH) E9(R1) guideline on estimands, which describes an aligned framework for planning, conducting, and analyzing clinical trials as well as interpreting sensitivity analyses. We also draw connections to earlier work by Lewis Sheiner.