Oxymatrine Extends Survival by Attenuating Neuroinflammation in a Mouse Model of Amyotrophic Lateral Sclerosis

•Oxymatrine improves motor performance and delays disease progression in ALS mice.•Oxymatrine attenuates motor neuron loss, microgliosis, and astrogliosis in ALS mice.•Oxymatrine regulates the gene expression of inflammation-related factors in ALS mice.•Oxymatrine modulates the gene expression of insulin signaling molecules in ALS mice.